Fatigue
Occurs in about 80% of people, can significantly interfere with ability to function at home and work, and may be the most prominent symptom in a person who otherwise has minimal activity limitations.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Fatigue

Walking (Gait) Difficulties
Related to several factors including weakness, spasticity, loss of balance, sensory deficit and fatigue, and can be helped by physical therapy, assistive therapy and medications.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Walking-Gait-Balance-Coordination

Numbness or Tingling
Numbness of the face, body, or extremities (arms and legs) is often the first symptom experienced by those eventually diagnosed as having MS.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Numbness

Spasticity
Refers to feelings of stiffness and a wide range of involuntary muscle spasms; can occur in any limb, but it is much more common in the legs.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Spasticity

Weakness
Weakness in MS, which results from deconditioning of unused muscles or damage to nerves that stimulate muscles, can be managed with rehabilitation strategies.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Weakness

Vision Problems
The first symptom of MS for many people. Onset of blurred vision, poor contrast or color vision, and pain on eye movement can be frightening — and should be evaluated promptly.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Vision-Problems

Dizziness and Vertigo
People with MS may feel off balance or lightheaded, or — much less often — have the sensation that they or their surroundings are spinning (vertigo).
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Dizziness-and-Vertigo

Bladder Problems
Bladder dysfunction, which occurs in at least 80% of people with MS, usually can be managed quite successfully through dietary and fluid management, medications, and catheterization.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Bladder-Dysfunction

Sexual Problems
Very common in the general population including people with MS. Sexual responses can be affected by damage in the central nervous system, as well by symptoms such as fatigue and spasticity, and by psychological factors.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Sexual-Dysfunction

Bowel Problems
Constipation is a particular concern among people with MS, as is loss of control of the bowels. Bowel issues can typically be managed through diet, adequate fluid intake, physical activity and medication.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Bowel-Problems

Pain
Pain syndromes are common in MS. In one study, 55% of people with MS had "clinically significant pain" at some time, and almost half had chronic pain.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Pain

Cognitive Changes
Refers to a range of high-level brain functions affected in 50% of people with MS, including the ability to learn and remember information, organize and problem-solve, focus attention and accurately perceive the environment.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Cognitive-Changes

Emotional Changes
Can be a reaction to the stresses of living with MS as well as the result of neurologic and immune changes. Bouts of depression, mood swings, irritability, and episodes of uncontrollable laughing and crying pose significant challenges for people with MS and their families.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Emotional-Changes

Depression
Studies have suggested that clinical depression — the severest form of depression — is more frequent among people with MS than it is in the general population or in persons with other chronic, disabling conditions.
https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Depression